Medical Microbiology 6th edition by Murray Patrick R. Rosenthal – Test bank

 

 

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Sample Test

Murray: Medical Microbiology, 6th Edition

 

Chapter 03: Bacterial Metabolism and Genetics

 

Test Bank

 

MULTIPLE CHOICE

 

1.    Ambient air, which contains 21% oxygen (O2) and a small amount (0.03%) of carbon dioxide (CO2), is the environmental condition that best suits which type of organism?

a.

Aerobes

b.

Anaerobes

c.

Capnophiles

d.

Microaerophiles

 

ANS: A

 

2.    From 5% to 10% hydrogen (H2), 5% to 10% CO2, 80% to 90% nitrogen (N2), and 0% O2 is the environmental condition that best suits which type of organism?

a.

Aerobes

b.

Anaerobes

c.

Capnophiles

d.

Microaerophiles

 

ANS: B

 

3.    Which of the following is not generated during anaerobic metabolism of glucose?

a.

Acetyl CoA

b.

Citrate

c.

Glucose-6-phosphate

d.

Glyceraldehyde-3-phosphate

e.

Pyruvate

 

ANS: B

 

4.    How many more ATP molecules are produced by aerobic respiration than by glycolysis?

a.

2

b.

4

c.

10

d.

36

e.

100

 

ANS: D

5.    Which of the following intermediates is generated upon metabolism of lactose by fermentation, aerobic respiration, and anaerobic respiration?

6.    Succinate

7.    Pyruvate

8.    Lactic acid

9.    Malate

10.  Citrate

 

ANS: B

 

6.    What is the term for pieces of DNA that move from one genetic element to another and contain genes for movement, as well as genes for other features?

a.

Transposons

b.

Insertion sequences

c.

Plasmids

d.

Chromatoids

 

ANS: A

 

7.    What is the term for “miniature” chromosomes composed of several genes in double-stranded, closed, circular structures?

a.

Transposons

b.

Insertion sequences

c.

Plasmids

d.

Chromatoids

 

ANS: C

 

8.    A DNA sequence that encodes for a specific product (RNA or protein) is defined as which of the following?

a.

Gene

b.

Genome

c.

Nucleotide

d.

Deoxyribonucleic acid

 

ANS: A

 

9.    What are the enzymes that add nucleotide bases to each growing daughter strand in the replication process called?

a.

Replication enzymes

b.

DNA polymerases

c.

Insertion sequence enzymes

d.

Transcriptases

 

ANS: B

 

10.  Genetic change in bacteria is accomplished by which of the following?

a.

Mutation

b.

Genetic recombination

c.

Gene exchange between bacteria

d.

All of the above

 

ANS: D

 

11.  Analysis of the DNA from methicillin- and vancomycin-resistant, gram-positive, coagulase-positive cocci isolated from a furuncle on a diabetic patient’s toe indicated the presence of DNA sequences from enterococci. Which of the following processes generated these new bacteria?

a.

Lysogeny

b.

Restriction enzyme cleavage

c.

Transduction

d.

Transformation

e.

Transversion

 

ANS: D

 

12.  Development of new strains of bacteria from the DNA of killed bacteria can occur by which genetic mechanism?

a.

Complementation

b.

Conjugation

c.

Transformation

d.

Transduction

e.

Transposition

 

ANS: C

 

13.  Which of the following would promote the metabolism of galactose by E. coli?

a.

Binding of CAP to the operon

b.

Binding of cAMP to CAP

c.

Binding of galactose to CAP

d.

Binding of glucose to the repressor

e.

Binding of galactose to the promoter

 

ANS: B

 

14.  Why would a frameshift mutation in the gene for topoisomerase 1 be lethal for E. coli but not C. albicans?

a.

C. albicans is lysogenic.

b.

C. albicans is diploid.

c.

For C. albicans, topoisomerase 1 is encoded on a plasmid.

d.

Frameshift mutations are corrected by heterologous recombination in C. albicans.

e.

Topoisomerase 1 is not important for E. coli.

 

ANS: B

 

15.  An E. coli with a mutation in topoisomerase 1 can grow at 28° C but not at 37° C. Which of the following changes in the protein would explain this temperature sensitive mutation?

16.  Frame shift mutation

17.  Nonsense mutation

18.  Missense mutation

19.  Null mutation

20.  Silent mutation

 

ANS: C

 

16.  Unlike for eukaryotes, excessive tryptophan can down-regulate production of the enzymes for tryptophan production in bacteria by:

17.  Binding to a repressor for protein synthesis

18.  Binding to a promoter for protein synthesis

19.  Activation of cAMP production

20.  Attenuation of transcription of operon mRNA

 

ANS: D

 

Murray: Medical Microbiology, 6th Edition

 

Chapter 04: Viral Classification, Structure, and Replication

                                      

Test Bank

 

MULTIPLE CHOICE

 

1.    Herpes simplex virus was genetically engineered as a gene delivery vehicle. Insertion of the new gene into which of the viral genes would prevent replication of the virus in all cells?

a.

DNA-dependent DNA polymerase

b.

DNA-dependent RNA polymerase

c.

RNA-dependent DNA polymerase

d.

RNA-dependent RNA polymerase

e.

Thymidine kinase

 

ANS: A

 

2.    An outbreak of gastroenteritis occurred on a cruise ship. A stool sample from one of the passengers contained a very small detergent-resistant virus. What other parameter would be true for this virus?

a.

Also causes pharyngitis

b.

Also causes paralysis

c.

Double-stranded RNA genome

d.

Enveloped

e.

Infectious genome

 

ANS: E

 

3.    A 34-year-old woman is jaundiced, has fever and nausea, lacks appetite, and has abdominal pain. She claims that the disease signs started 3 days earlier. A stool sample contained a small detergent-resistant virus. Which of the following describes a likely consequence of this infection?

a.

Cancer

b.

Chronic infection

c.

Complete recovery 99%

d.

Fulminant disease

e.

Serum immune complexes

 

ANS: C

 

4.    A 34-year-old woman has been feeling very tired for several months, and blood tests showed elevated levels of liver enzymes. A blood sample tested positive for viral antigen and RNA for a +RNA virus, but no virus could be grown from the serum or seen in this or other samples. Which of the following describes the most likely consequence of this infection?

a.

Cancer

b.

Chronic infection

c.

Complete recovery 99%

d.

Fulminant disease

e.

Serum immune complexes

 

ANS: B

 

5.    A 3-year-old child has a group of lesions that include vesicles, crusted vesicles, and ulcers around the corner of his mouth. A Tzanck smear shows Cowdry type A inclusion bodies. Which is the most appropriate description for this microbe?

a.

Genome is a circular small DNA.

b.

Genome replication occurs in the cytoplasm.

c.

Gene transcription occurs in three phases.

d.

Translation results in a polyprotein.

e.

Two different types of +RNAs are produced during virus replication.

 

ANS: C

 

6.    During the course of HIV infection of a person, the target cell changes from macrophages and some CD4 T cells to include other CD4 T cells. A mutation in which viral protein would most likely account for this change?

a.

RNA-dependent DNA polymerase

b.

GP120

c.

Integrase

d.

TAT

e.

REV

 

ANS: B

 

 

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